SAHPRA is warning the public about the growing availability and use of unregistered peptide products, including certain GLP-1 medicines, being unlawfully marketed in South Africa. This page outlines the risks, legal requirements, and how to identify safe, approved products to protect your health.
Public Warning
The South African Health Products Regulatory Authority (SAHPRA) warns of the growing sale and use of unregistered peptide products in South Africa.
These products are often promoted for:
- Weight loss
- Muscle growth
- Anti-ageing
- Injury recovery
- Improved concentration
- Enhanced performance
Illegal Distribution
Many of these products are sold unlawfully through:
- Online platforms
- Social media
- Gyms and wellness centres
- Informal suppliers
These sales occur without approval under the Medicines and Related Substances Act, 101 of 1965.
Examples
Illegally marketed peptides include: BPC-157, TB-500, Melanotan II, CJC-1295, Ipamorelin, PT-141, AOD-9604, Selank, and Semax.
Regulatory Requirement
Under Medicines and Substances Act 101 of 1965, any product intended to treat, prevent, or alter bodily functions must be registered with SAHPRA before it can be sold in South Africa.
This ensures safety, quality, and effectiveness.
Safety Warning
SAHPRA warns against self-administration without medical supervision, especially for products purchased online or from unverified sources.
Suspected illegal sales should be reported.
Commitment
SAHPRA remains committed to ensuring all health products meet required safety, quality, and efficacy standards.
Health Risks
Unregistered peptide products may pose serious risks, including:
Infections from injectable use
Hormonal disruption
Harmful drug interactions
Possible tumour stimulation
Unknown long-term effects
Exposure to counterfeit or contaminated products
Warning: Avoid using unregistered peptides.
Advice on GLP-1 Products
Use legitimate products only
- In original packaging
- From licenced manufacturers
- Prescribed by registered healthcare professionals
- Dispensed by licenced pharmacists
Avoid risky sources
Products from social media, online vendors, gyms, or informal suppliers are likely counterfeit or substandard.
Check product form and price
- Registered GLP-1 products are supplied as ready-to-use (e.g., pre-filled pens or vials).
- Powder forms are not registered and should be treated with caution.
- Unusually low prices often indicate counterfeit or illegally manufactured products.
SAHPRA calls on the public and all stakeholders — healthcare professionals, pharmacists, manufacturers, distributors, and retailers — to:
- Protect the integrity of the medicine supply chain
- Safeguard public health
Shared Responsibility
Medicines regulation is a collective responsibility. All stakeholders play a vital role in ensuring only safe and effective products are available.
Please report adverse side effects to SAHPRA at adr@sahpra.org.za