Variations Guideline for Human and Veterinary Medicines

Variations Guideline for Human and Veterinary Medicines

This document provides recommendations for applicants submitting variation applications for human and veterinary medicines. In addition to this guideline, the South African Health Products Regulatory Authority (SAHPRA) reserves the right to request additional information to establish the safety, quality and efficacy of a medicine based the knowledge available at the time of evaluation. SAHPRA is committed to ensuring that all registered medicines meet the required quality, safety and efficacy.

 

View Variations Addendums

 

Application Letter Template: Post-registration Variations

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Document Number: SAHPGL-HPA-06
Version: 7
Date Updated: 09/06/2026
File Type: www
Category: Guideline
Unit: General ECTD & human medicines, HPA, Veterinary medicines