DHCPL for ACE-inhibitor/Angiotensin receptor blocker containing medicines

17 Aug DHCPL for ACE-inhibitor/Angiotensin receptor blocker containing medicines

Posted at 12:48h in

In collaboration with the South African Health Products Regulatory Authority (SAHPRA), Novartis SA (Pty) Ltd would like to inform you of a risk of acute kidney injury (AKI) in patients treated concomitantly with Angiotensin Converting Enzyme Inhibitors (ACEIs) /Angiotensin receptor blockers (ARBs) and fluoroquinolones. ...

Read More

17 Aug Fluoroquinolones: risk of mitral and aortic regurgitation associated with the use of oral and injectable fluoroquinolones

Posted at 12:47h in

In collaboration with the South African Health Products Regulatory Authority (SAHPRA), the companies listed below would like to inform you about the risk of mitral and aortic regurgitation that should be taken into consideration when prescribing oral fluoroquinolone antibiotics. ...

Read More

17 Aug Sandoz and Novartis: Warning about small increased risk of oral clefts following use in the first 12 weeks of pregnancy

Posted at 12:45h in

In collaboration with the South African Health Products Regulatory Authority (SAHPRA), the below listed companies would like to inform you of an increased risk of cleft lip and/or cleft palate following the use of ZOFRAN® (ondansetron) during the first 12 weeks of pregnancy. ...

Read More

17 Aug Ondansetron: Warning about small increased risk of oral clefts following use in the first 12 weeks of pregnancy

Posted at 12:45h in

In collaboration with the South African Health Products Regulatory Authority (SAHPRA), the below listed companies would like to inform you of an increased risk of cleft lip and/or cleft palate following the use of ondansetron during the first 12 weeks of pregnancy....

Read More

17 Aug Tyrosine kinase inhibitors

Posted at 12:41h in

The pharmaceutical companies mentioned below, in collaboration with South African Health Products Regulatory Authority (SAHPRA), wish to inform you of the class related cerebrovascular adverse events reported with the use of tyrosine kinase inhibitor (TKI) containing medicines. The Professional Information (PI) and Patient Information Leaflet...

Read More

17 Aug Fluoropyrimidine containing medicines and related substances: Increased drug exposure and toxicity in patients with dihydropyrimidine dehydrogenase (DPD) deficiency

Posted at 12:38h in

In collaboration with the South African Health Products Regulatory Authority (SAHPRA), the companies listed below would like to inform you of the requirement of pre-testing to identify patients at increased risk of severe toxicity due to fluoropyrimidine containing medicines....

Read More

17 Aug Risk of dopamine dysregulation syndrome (DDS) associated with the use of dopaminergic medicines used for the treatment of Parkinson’s disease (PD).

Posted at 12:37h in

The pharmaceutical companies mentioned below, in collaboration with South African Health Products Regulatory Authority (SAHPRA), wish to inform you of the risk of dopamine dysregulation syndrome (DDS) associated with the chronic use of dopaminergic medicines used for the treatment of Parkinson’s disease. The Professional Information...

Read More

17 Aug Tecentriq® (atezolizumab): Risk of Severe Cutaneous Adverse Reactions (SCARs) and Immune-related myositis

Posted at 12:36h in

In collaboration with the South African Health Products Regulatory Authority (SAHPRA), Roche Products (Pty) Ltd would like to inform you of the risk of Severe Cutaneous Adverse Reactions (SCARs) and immune-related myositis associated with the use of Tecentriq® (azeolizumab)....

Read More

17 Aug Dopaminergic medicines used in the treatment of parkinson’s disease: Risk of Dopamine dysregulation syndrome

Posted at 12:34h in

2020 Oct...

Read More

17 Aug Diphenhydramine-containing Medicines

Posted at 12:32h in

The South African Health Products Regulatory Authority (SAHPRA) wishes to alert healthcare professionals about the risk of serious heart problems, seizures, coma and death associated with the use of high doses of diphenhydramine-containing medicines. An online challenge known as “the Benadryl Challenge” has recently been...

Read More